Early Wash-out (< 60 Seconds) at Contrast-Enhanced Ultrasonography in Liver Nodules in Cirrhosis is Highly Suggestive for Non-Hepatocellular Carcinoma Malignancy

Purpose: Contrast-Enhanced Ultrasonography (CEUS) was recommended for detection and characterization of liver nodules, with same diagnostic accuracy as contrast computed tomography (CT) scan and dynamic magnetic resonance imaging (MRI). However, this procedure has been dropped from the diagnostic algorithm of liver malignancy in the update American Association for the Study of Liver Diseases guidelines 2011, because of false positive hepatocellular carcinoma (HCC) diagnosis in patients with cholangiocarcinoma. The present study aimed to assess the role of CEUS in diagnosis of liver non-HCC malignancy.