Evidence of AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts and its Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna S. Man Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y. Chew, Chao Wang, Sanja Bosnyak, Katrina M. Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth K.M. Johnstone, Mohammed A. Hossain, Kevin D.G. Pfleger, Kate M. Denton, Robert E. Widdop, Roger J. Summers, Ross A.D. Bathgate, Tim D. Hewitson, and Chrishan S. Samuel Cardiovascular Disease Program, Biomedicine Discovery Institute and Departments of Pharmacology and Physiology, Monash University, Clayton Victoria 3800; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052 Australia; Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria 3050; Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia; ARC Centre for Personalised Therapeutics Technologies; Dimerix Limited, Nedlands, Western Australia 6009, Australia; and Department of Medicine, University of Melbourne, Parkville, Victoria 3050