Genomic and Transcriptomic Somatic Alterations of Hepatocellular Carcinoma in Non-Cirrhotic Livers

Cancer Genetics（2022）

引用 4|浏览6
摘要
•Non-cirrhotic HCC genomically resembles cirrhotic HCC•Comprehensive genome- and transcriptome-wide profiling allows detection of novel structural variants, fusions, and undiagnosed viral infections•NR1H4 fusions may represent a novel mechanism for tumorigenesis in HCC•Non-cirrhotic HCC is characterized by genotoxic mutational signatures and dysregulated liver metabolism•Clinical history and comprehensive omic profiling incompletely explain underlying etiologies for non-cirrhotic HCC highlighting the need for further research
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关键词
Non-cirrhotic,HCC,APOB,NR1H4
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