Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease

Key Points Question Is time-restricted eating more effective in improving nonalcoholic fatty liver disease than daily calorie restriction? Findings In this randomized clinical trial including 88 patients with obesity and nonalcoholic fatty liver disease, the intrahepatic triglyceride content was reduced by 6.9% in the time-restricted eating group and 7.9% in the daily calorie restriction group during 12 months, but with no significant between-group differences. Time-restricted eating also did not produce additional benefits for reducing body fat or major metabolic risk factors compared with daily calorie restriction. Meaning The findings of this randomized clinical trial support the importance of caloric restriction with use of time-restricted eating among adults with obesity and nonalcoholic fatty liver disease.