Supplementary Methods, Figures 1 - 3 from Sequential Application of a Cytotoxic Nanoparticle and a PI3K Inhibitor Enhances Antitumor Efficacy

PDF file - 251K, Fig. 1S: Depiction of drug model for nanoparticle release and delayed transmembrane transport of self-assembling cis-platinum nanoparticles (SACNs) and free cisplatin in an acidic environment. Fig. 2S: Flowchart showing the computational algorithm used to fit parameters in the mathematical model. Fig. 3S: (Data points) The release profile of cisplatin nanoparticles was evaluated at 37 degrees C in neutral and acidic (tumor like) pH in triplicates.