Delayed-type Allergic Reaction to Furazolidone: A Case Report and Review of the Literature

BackgroundFurazolidone is a nitrofuran antimicrobial agent used in the treatment of bacterial and protozoal infections. Hypersensitivity to furazolidone is rarely reported and only eight cases have been documented in English since 1967.ObjectivesTo report a 24-year-old man who developed exanthematous drug eruptions in general and swelling sensation of the hands after first dose of oral administration of medicines for Helicobacter pylori infection 7 h later, who was finally confirmed with delayed-type IV allergic reaction to furazolidone by provocation tests. And to review the existing literature.MethodsThorough clinical examination, prick, intradermal, and patch tests, drug provocation tests were performed in the patient.ResultsSkin tests of all used drugs were negative. Drug provocation tests to furazolidone resulted to be positive.ConclusionsClinicians should be aware that furazolidone may induce delayed-type allergic reactions; diagnostic approaches should be taken to identify the responsible drug when multiple medications were used concurrently. Hypersensitivity to furazolidone is rare. Furazolidone may cause delay type allergic reaction when treat H. pylori infection.image