Linking ALS Mutations to the Disruption of the MHC-II Pathway.

The ribosome is a macromolecular machine that undergoes global conformational rearrangements during translation, that involve coupled movements of ribosomal subunits, tRNAs, and the L1 stalk. However, there is a disagreement between different ...The two main steps of translation, peptidyl transfer, and translocation are accompanied by counterclockwise and clockwise rotations of the large and small ribosomal subunits with respect to each other. Upon peptidyl transfer, the small ribosomal subunit ...