CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)

Circulating Pathogenic Factors Circulating pathogenic factor for FSGS development has long been searched. In article number 2301492, Ke Zen, Zhihong Liu, and co-workers identify exosomal miR-186-5p from activated CD8 T cells as such circulating pathogenic factor that causes renal dysfunction. In specific, miR-186-5p is enriched in exosomes of activated CD8 T cells and preferentially enters renal tubular cells where it directly binds endosomal TLR7/8 and initiates renal inflammation.