Hot Issues in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive disease with a poor prognosis. Several clinical trials have demonstrated future prospects for patients with TNBC based on improved long-term survival; however, there are still TNBC challenges, such as molecular classification and treatment optimization. Invited by Cancer Biology & Medicine, we would like to discuss four hot topics in TNBC and suggest some potential solutions (Figure 1). What are the new advances in the molecular classification of TNBC and the significance for clinical practice?