Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation Via Cgas‐sting Axis in Spinal Cord Injury (adv. Sci. 4/2024)

Advanced ScienceVolume 11, Issue 4 2470021 Cover PictureOpen Access Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury (Adv. Sci. 4/2024) Fei-Long Wei, Fei-Long WeiSearch for more papers by this authorTian-Fu Wang, Tian-Fu WangSearch for more papers by this authorChao-Li Wang, Chao-Li WangSearch for more papers by this authorZhen-Peng Zhang, Zhen-Peng ZhangSearch for more papers by this authorJing-Wei Zhao, Jing-Wei ZhaoSearch for more papers by this authorWei Heng, Wei HengSearch for more papers by this authorZhen Tang, Zhen TangSearch for more papers by this authorMing-Rui Du, Ming-Rui DuSearch for more papers by this authorXiao-Dong Yan, Xiao-Dong YanSearch for more papers by this authorXiao-Xiang Li, Xiao-Xiang LiSearch for more papers by this authorZheng Guo, Zheng GuoSearch for more papers by this authorJi-Xian Qian, Ji-Xian QianSearch for more papers by this authorCheng-Pei Zhou, Cheng-Pei ZhouSearch for more papers by this author Fei-Long Wei, Fei-Long WeiSearch for more papers by this authorTian-Fu Wang, Tian-Fu WangSearch for more papers by this authorChao-Li Wang, Chao-Li WangSearch for more papers by this authorZhen-Peng Zhang, Zhen-Peng ZhangSearch for more papers by this authorJing-Wei Zhao, Jing-Wei ZhaoSearch for more papers by this authorWei Heng, Wei HengSearch for more papers by this authorZhen Tang, Zhen TangSearch for more papers by this authorMing-Rui Du, Ming-Rui DuSearch for more papers by this authorXiao-Dong Yan, Xiao-Dong YanSearch for more papers by this authorXiao-Xiang Li, Xiao-Xiang LiSearch for more papers by this authorZheng Guo, Zheng GuoSearch for more papers by this authorJi-Xian Qian, Ji-Xian QianSearch for more papers by this authorCheng-Pei Zhou, Cheng-Pei ZhouSearch for more papers by this author First published: 26 January 2024 https://doi.org/10.1002/advs.202470021AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Spinal Cord Injury After spinal cord injury, the mitochondrial DNA of microglia escapes into the cytoplasm, thereby triggering the activation of the cGas-Sting pathway, which in turn initiates the activation of pro-inflammatory signals and the subsequent release of inflammatory factors, ultimately leading to neuronal cell death. More details can be found in article number 2305442 by Zheng Guo, Ji-Xian Qian, Cheng-Pei Zhou, and co-workers. Volume11, Issue4January 26, 20242470021 RelatedInformation