Multidimensional profile of gut microbiota in a large cohort of stratified rheumatoid arthritis
crossref(2024)
摘要
Abstract It is unknown if dysbiosis of microbiota plays a role in the initiation and severity of rheumatoid arthritis (RA). In a comprehensive study of 2297 individuals, including 1,064 RA patients and 1,233 healthy controls, we uncovered an age-related trajectory fluctuation of intestinal microbiota in RA which clearly coincided with the peak age of RA onset. Patients at RA onset exhibited a significant reduction in anti-inflammatory species like Akkermansia muciniphila, Butyrivibrio proteoclasticus, and Rumlnococcus albus. Conversely, pro-inflammatory bacteria Escherchia coli, Parabacteroldes distesonis, and Velllonella parvula were largely enriched. Samples in different clusters show distinct microbial patterns, and associated with treatment response. Specific gut microbiota was closely linked to RA's clinical features and systemic involvements, especially interstitial lung disease (ILD). Our predictive model based on gut microbiota successfully distinguished RA with systemic impairment from those with mainly joint involvements. Additionally, a 6-year follow-up cohort showed that lower disease activity associated with increased abundance of Streptococcu salivarius, Anaerostipehadrus, and lactobacillus fermentum. These findings suggest that gut microbiota may trigger RA initiation, and are associated with aggravated and systemic damages of the disease, and could lead to more personalized and effective treatment strategies.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn