2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: Synthesis, Structure and in Vitro Study of the Activity Against Influenza Virus

MENDELEEV COMMUNICATIONS（2024）

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摘要
Alkyl (2E)-2-[2-(phenylcarbamoyl)hydrazinylidene]- propanoates were prepared from 3-nitroacrylates and N-phenylhydrazinecarboxamide. Their fine structure was confirmed by NMR and X-ray data. Cytotoxicity and antiviral activity against the A/Puerto Rico/8/34 (H1N1) influenza virus strain in MDCK cell culture were determined for the obtained compounds.
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nitroacrylates,N-phenylhydrazinecarboxamide,nucleophilic addition,aza-Michael adduct,hydrazone,biological activity
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