Generation of a Human Induced Pluripotent Stem Cell Line (Yucmi020-A) from Peripheral Blood Mononuclear Cells Derived from a Female with the Jr(a−) Blood Type
Stem Cell Research(2024)
摘要
The Jra antigen, the only antigen within the JR blood group system, is a high -prevalence red blood cell (RBC) antigen found in over 99 % of the global population. An induced pluripotent stem cell line (YUCMi020-A) was generated from peripheral blood drawn from a Jr(a-) phenotype individual, who was homozygous for a null mutation of ABCG2*01N.01 (rs72552713, c.376C >T; p.Gln126*). The generated line exhibited pluripotent characteristics and no chromosomal aberrations. This cell line will serve as a cell source, enabling us to produce RBCs with the Jr(a-) phenotype in vitro, which can be used for transfusing individuals with anti-Jra antibodies.
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