Frailty in Patients on Dialysis

Frailty is a condition that is frequently observed among patients performing dialysis. It is characterised by a decline in both physiological and cognitive state, leading to a combination of symptoms such as weight loss, exhaustion, low physical activity, weakness, and slow walking speed. Frail patients not only experience a poor quality of life, but they are also at a higher risk of hospitalization, infection, cardiovascular events, dialysis-associated complications, and death.Frailty occurs as a result of a combination and interaction of various medical issues in patients who are on dialysis. Unfortunately, there is no cure for frailty. To address frailty, a multifaceted approach is necessary, involving coordinated efforts from nephrologists, geriatricians, nurses, allied health practitioners, and family members. Strategies such as optimizing nutrition and CKD-related complications, reducing polypharmacy by deprescription, personalized dialysis prescription and considering home-based or assisted dialysis may help slow the decline of physical function over time in subjects with frailty.This review discusses the underlying causes of frailty in patients on dialysis and examines the methods and difficulties involved in managing frailty among this group.