Effect of Multitarget Faecal Immunochemical Testing on Colorectal Cancer Screening Strategies

We commend the study by Pieter H A Wisse and colleagues 1 Wisse PHA de Klaver W van Wifferen F et al. The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention study. Lancet Oncol. 2024; 25: 326-337 Summary Full Text Full Text PDF PubMed Scopus (1) Google Scholar on advancing colorectal cancer screening with the multitarget faecal immunochemical test (mtFIT). Colorectal cancer screening is a crucial public health strategy, balancing the burden of the disease with the feasibility of acceptable screening modalities. 2 Ladabaum U Dominitz JA Kahi C Schoen RE Strategies for colorectal cancer screening. Gastroenterology. 2020; 158: 418-432 Summary Full Text Full Text PDF PubMed Scopus (318) Google Scholar This pivotal research shows mtFIT's potential to greatly improve advanced neoplasm detection rates without sacrificing specificity, suggesting a promising avenue for efficiently reducing colorectal cancer incidence and mortality. By leveraging a prospective design, large participant base, and comprehensive outcomes, the study robustly evaluates mtFIT's real-world applicability. The study's inclusive participant demographic and multi-institutional collaboration further enhance its relevance, making a substantial contribution toward mitigating the global colorectal cancer burden. The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention studyThe higher detection rate of mtFIT for advanced adenoma compared with FIT holds the potential to translate into additional and clinically meaningful long-term colorectal cancer incidence and associated mortality reductions in programmatic colorectal cancer screening. Full-Text PDF