Transformation of Natural Resin Resina Draconis to 3D Functionalized Fibrous Scaffolds for Efficient Chronic Wound Healing

Chronic wound healing is a major challenge in clinical practice. Secondary dressing damage and antibiotic resistance are the main obstacles for traditional wound dressings. Resina Draconis (RD), a natural resin traditionally used in powder form for wound care, is now considered unsuitable due to the lack of gas permeability and moist environment required for wound healing. Here, we incorporated RD in situ by constructing a 3D coiled fibrous scaffold with polycaprolactone (PCL)/polyethylene oxide (PEO). Due to the high porosity of 3D scaffold, the RD‐3D dressings have a favorable swelling capacity, providing permeability and moisture for wound repair. Meanwhile, the transformation of RD powder into 3D dressings fully demonstrated capabilities of RD in rapid hemostasis, bactericidal and inflammation‐regulating activities. In vivo evaluations using pressure ulcer and infected wound models confirmed the high efficacy of RD‐3D dressing in early wound healing, particularly beneficial in the infected wound model compared to bFGF. Further biological analysis showed that resveratrol, loureirin A and loureirin B, as potentially bioactive components of RD, individually contributed to different aspects of wound healing. Collectively, RD‐3D integrated dressings represent a simple, cost‐effective and safe approach to wound healing, providing an alternative therapy for translating medical dressings from bench to bedside. This article is protected by copyright. All rights reserved