Thymic Epithelial Tumour Size Reduction after Steroid Therapy Without Chemotherapy: A Possible Tumour Treatment? Case Report and Literature Review

Journal on Oncology(2024)

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摘要
Myasthenia Gravis (MG) is a neuromuscular junction disorder characterised by antibodies directed against postsynaptic antigens (mainly the Acetylcholine Receptors (AChR)). The management of MG symptoms relies on the utilization of anticholinesterases (such as Pyridostigmine), immunosuppressive and immunomodulatory therapies, including therapeutic plasmapheresis or high-dose human immunoglobulin. The removal of thymoma presents an oncological “urgency», in the context of myasthenic patients, it is crucial to undertake the operation solely when myasthenic symptoms are effectively controlled by pharmacological therapy. A literature review was conducted on Pubmed with the terms “thymoma” and “steroid” to explore the role of steroids, administrated for MG treatment in tumor dimension reduction. To date, only a limited number of studies have investigated the effect of steroids on tumour size, particularly in the context of thymoma, which is relatively rare. Finally we presented the case of a 53-year-old male patient affected of a severe form of MG and a thymoma with suspicious infiltration of anonymous vein, who was treated with high doses of steroids, with final control on MG symptoms and tumor dimension reduction. The patients was at the end operated successfully with a robot assisted technique.
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