Figure 5 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer

Oxygen-responsive gene expression of Cutibacterium within model tumors. A, Volcano plot of metatranscriptomic analysis of transcripts from Cutibacterium found in low or high hypoxia score CT26 tumors grown in either immune-deficient or immune-competent host animals (1,295 total transcripts identified). B, Bar plot showing the total number of significantly enriched genes in the hypoxic and normoxic conditions enriched in each enzyme class as notated in (A). C, Table of the 34 annotated transcripts that showed significant concordant changes to hypoxia score in both datasets (48 total, 39 pos, and 9 neg).