Figure 3 from Race-Related Differences in Sipuleucel-T Response among Men with Metastatic Castrate–Resistant Prostate Cancer

Co-stimulatory and co-inhibitory marker expression on CD4+ and CD8+ T cells in two racial groups. A, No differences in the percentage of CD4+ T cells were observed at baseline or at 10 weeks post-treatment in AA men (n = 29) vs. non-AA men (n = 28). Expression of co-stimulatory receptor ICOS on CD4+ T cells was significantly higher at baseline and at 10 weeks post-treatment (P = 0.0006; P = 0.0027, respectively) in AA men compared to non-AA men. Expression of co-inhibitory receptor BTLA on CD4+ was also significantly higher at baseline (P < 0.0001) in AA men compared to non-AA men. B, The percentage of CD8+ T cells was significantly lower (P = 0.0016) at baseline as well as at 10 weeks post- treatment in AA men compared to non-AA men. Expression of co-stimulatory receptor ICOS on CD8+ T cells was significantly higher at baseline and at 10 weeks post-treatment (P = 0.0023; P = 0.0026, respectively) in AA men vs. non-AA men. Differences between the two racial groups were analyzed by the Mann–Whitney test and P values < 0.0032 were considered as significant in the multiple comparisons sense. The horizontal line in each dot plot marks the median value. Base, baseline; wks, weeks.