Development of Neural Cells and Spontaneous Neural Activities in Engineered Brain-Like Constructs for Transplantation
Advanced healthcare materials(2024)
摘要
Stem cell transplantation has demonstrated efficacy in treating neurological disorders by generating functional cells and secreting beneficial factors. However, challenges remain for current cell suspension injection therapy, including uncontrollable cell distribution, the potential for tumor formation, and limited ability to treat spatial defects. Therefore, implants with programmable cell development, tailored 3D structure, and functionalized biomaterials have the potential to both control cell distribution and reduce or heal spatial defects. Here, a biomimetic material system comprising gelatin, alginate, and fibrinogen has been developed for neural progenitor cell constructs using 3D printing. The resulting constructs exhibit excellent formability, stability, and developmental functions in vitro, as well as biocompatibility and integration into the hippocampus in vivo. The controllability, reproducibility, and material composition of the constructs show potential for use in personalized stem cell-based therapies for defective neurological disorders, neural development research, disease modeling, and organoid-derived intelligent systems. This work provides a 3D printable biomimetic material that can support stable brain-like constructs based on neural progenitor cells (NPCs) in long-term culture, showing in vitro development and in vivo brain integration. This breakthrough offers potential for personalized stem cell therapies for neurological disorders, while also advancing research in neural development, disease modeling, and organoid-derived intelligent systems. image
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关键词
bioprinting,brain-like constructs,neural development,neural progenitor cells,stem cell therapy
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