Supplementary Figure S1 from Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation

Figure S1: Demonstration of the method of reconstruction of patient-level data from published Kaplan-Meier plots. Kaplan-Meier plots from published manuscripts were imported into WebPlot Digitizer, where event times for each Kaplan-Meier curve were manually selected. This data, along with the numbers ta risk corresponding to each time interval in the original Kaplan-Meier graph, was then converted into a CSV file. Data from this file was used to calculate the RMST difference using the survRM2 function in R (version 1.0-4). K-M, Kaplan-Meier.