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Bidesh Mahata ,In 2011, he joined Teichmann Laboratory, MRC-Laboratory of Molecular Biology, Cambridge, UK, as an investigator scientist. There he discovered that T helper 2 lymphocytes upregulate Cyp11a1 expression, the enzyme that catalyses the first and rate-limiting step of steroid biosynthesis, and produce steroid hormones, possibly to resolve immune reactions and restore homeostasis. Fascinated by that discovery, he went on to develop discovery tools to study immune cell-mediated steroidogenesis. In 2013, the Teichmann Laboratory moved to the EMBL-EBI and Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. There he took initiatives to generate a novel Cyp11a1-mCherry reporter mouse line to track steroidogenic cells and a conditional knockout mouse line to ablate steroidogenesis cell type specifically. Using these discovery tools and with outstanding support from the Teichmann Laboratory (particularly in the area of single-cell genomics), he discovered that tumour infiltrating T cells, mast cells and basophils are steroidogenic and these steroidogenic immune cells are involved in anti-tumour immunosuppression. In 2019, he joined the Department of Pathology, University of Cambridge, UK, to lead a research team focussed on immune cell steroidogenesis.
研究兴趣
论文共 31 篇作者统计合作学者相似作者
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Debasis Banik,Christopher Ward, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh,Bing Li,Shekhar Kedia,Simon Davis,James Roy,Michael Chapman,Bidesh Mahata,David Klenerman
biorxiv(2024)
Luca F. Sandor, Joon B. Huh,Peter Benko,Toru Hiraga,Szilard Poliska,Csaba Dobo-Nagy,Joanna P. Simpson,Natalie Z. M. Homer,Bidesh Mahata,David S. Gyori
CELL REPORTSno. 3 (2024)
Frontiers in endocrinology (2023): 1323185-1323185
FRONTIERS IN ENDOCRINOLOGY (2023): 1323185-1323185
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