My research program focuses on obesity and comorbidities, including malignancies. My basic research efforts utilize genomics-bioinformatics, animal physiology, and molecular biology studies to elucidate the role of new molecules important in energy homeostasis.
As a practicing internist, endocrinologist, and dedicated educator, I have considered a pioneer and worldwide expert in obesity and metabolism. During my career, I have treated thousands of patients, mentored over 200 trainees and collaborators in my laboratory and beyond, and published over 1000 peer-reviewed articles that received 170,000 citations. I am also an educator who created and leads novel clinical training and education programs. My work has improved our understanding of the underlying pathophysiological mechanisms related to obesity, energy balance and metabolism, as well as related comorbidities including obesity related malignancies. My past and ongoing work has defined the role of the adipocyte-secreted hormone leptin in humans, and over the last years, the Mantzoros lab research has expanded to understand the physiology and the role of gastrointestinal hormones as well as the role of myokines and mitokines in obesity and obesity-related disorders and comorbidities. Our work has also resulted in patents for diagnostic and therapeutic applications, has directly contributed to the development of new pharmaceuticals by major pharmaceutical companies, and has contributed to the creation of new companies.