Our research is directed toward understanding the regulation and function of the signaling pathways, which play a central role in the mammalian stress response. In particular, we are interested in ubiquitin ligases and protein kinases that cooperate in the regulation of important cellular functions, including hypoxia, ER stress and cell cycle.
Accordingly, we focus on:
the ubiquitin ligase Siah2, which our lab discovered as an important regulator of prolyl hydroxylase and hypoxia,
the ubiquitin ligase RNF5, which is important in ER-stress response and
the kinase JNK in the context of cell cycle control, re-wired control in melanoma and impact on ER stress. Studies are also devoted to understanding of the transcription factor ATF2, which was discovered in our lab to play important role in DNA damage and ATM response.