His laboratory focuses on using nano- and microscale technologies to study cancer biology, especially tumor-stroma interactions. He invented the first layer-by-layer nanoparticle and demonstrated its use in spatiotemporally targeting angiogenesis and cancer cells, which led to founding of Cerulean Pharmaceuticals (NASDAQ-CRLX).
He co-founded multiple start-ups based on his inventions, including Farcast Biosciences, Vyome Biosciences, and Akamara Therapeutics Inc, and his start-ups have raised over $200M in venture/public funding and have drugs in clinical trials. Prof. Sengupta has published over 100 high impact papers, including in Nature, Nature Biomedical Engineering, Nature Nanotechnology, Nature Communication, ACS Nano and the PNAS; and is an inventor on over 350 pending/granted patents worldwide.